ag百家乐真的假的
Journal of Genetics and Genomics 2025年第2期(Volume 52, Issue 2, 2025) 在线发表，宽待各人下载阅读。
下载网址：
https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics/vol/52/issue/2
本期封面
Volume 52, Issue 2
On the cover: β-thalassemia is a common monogenic disorder. De-repression of γ-globin to compensate for β-globin deficiency represents a promising genetic therapy for β-thalassemia. Genome-wide association studies have identified transcription factors that drive γ-globin silencing in healthy adults with varying Hb F levels. In this issue, Luo et al. report that a previously unknown SNP, rs7948668, is significantly associated with higher Hb F levels and delays the disease onset (pp. 157–167). The cover image illustrates how the rs7948668 mutation (pink) disrupts the IKAROS binding motif, leading to the dissociation of the PYR Complex (purple). The altered spatial structure of the chromosome (transparent dome) enhances the competition of HBG promoters for locus control regions (red). As a result, γ-globin is activated (gold), ready to synthesize large amounts of fetal hemoglobin.
本期实质简介
Volume 52, Issue 2
Review
Epigenetic control of plant abiotic stress responses
Lijun Ma, Lihe Xing, Zicong Li, Danhua Jiang
https://doi.org/10.1016/j.jgg.2024.09.008
中国科学院遗传与发育生物学估量所姜丹华估量员团队发表综述论文，系统纪念连年来表不雅遗传调控在植物非生物约束反馈中的估量进展，先容非生物约束指导的植物表不雅遗传顾忌，并瞻望异日潜在的估量办法和表不雅遗传调控在作物阅兵中的应用价值。
Improving regulatory T cell-based therapy: insights into post-translational modification regulation
Aiting Wang, Yanwen Wang, Rui Liang, Bin Li, Fan Pan
https://doi.org/10.1016/j.jgg.2024.09.014
中国科学院深圳先进时候估量院潘璠教练团队与上海交通大学医学院上海市免疫学估量所李斌估量员团队联接发表综述论文，纪念Treg细胞阐扬免疫禁止功能的主要机制，系统弘扬卵白质翻译后修饰调控Treg细胞褂讪性和功能的估量进展，并参谋其在临床疾病诊疗中的应用。通过骚动这些翻译后修饰经过来调控Treg细胞的活性，有望为Treg细胞疗法在疾病中的临床应用开发新办法。
Original Research
Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia
Hualei Luo, Jueheng Wang, Lang Qin, Xinhua Zhang, Hailiang Liu, Chao Niu, Mengyang Song, Congwen Shao, Peng Xu, Miao Yu, Haokun Zhang, Yuhua Ye, Xiangmin Xu
https://doi.org/10.1016/j.jgg.2024.10.015
南边医科大学徐湘民教练团队发表估量论文，发现β-珠卵白基因簇内常见变异rs7948668通过松弛IKAROS结合位点，激活γ-珠卵白抒发，从而灵验平缓β-地中海贫血患者的临床表型，为β-地中海贫血诊疗提供了新靶点。(封面论文)
OsbZIP27 coordinates with OsHUB1 and OsHUB2 to modulate drought tolerance in rice
Zuntao Xu, Yachun Yang, Fei Zhang, Hao Li, Hui Ma, Wenge Wu, Yong Ding
https://doi.org/10.1016/j.jgg.2024.11.016
中国科学时候大学丁勇教练和安徽省农业科学院功能基因建造团队联接发表估量论文，揭示了转录因子OsbZIP27卵白协同组卵白H2B单泛素化修饰因子OsHUB1/2调控水稻干旱耐受的分子机制，为培育耐旱水稻品种提供基因资源和育种念念路。
Genome-wide association analysis reveals regulatory genes for the metabolite synthesis of 2-acetyl-1-pyrroline in aromatic coconut (Cocos nucifera L.)
Hao Ding, Xiang Lv, Guangzhen Zhou, Xiaomei Liu, Xiwei Sun, Jing Li, Amjad Iqbal, Yaodong Yang
https://doi.org/10.1016/j.jgg.2024.12.002
中国热带农业科学院椰子估量所杨耀东估量员团队发表估量论文，基于GWAS和单倍型分析马虎到2AP代谢调控伏击候选基因CnASN1，为高香型椰子育种提供了与2AP合成密切关连的分子标志。
TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation
Jee Young Sung, Ga-Eun Lim, Jarim Goo, Kyung Jin Jung, Jeong Min Chung, Hyun Suk Jung, Yong-Nyun Kim, Jaegal Shim
https://doi.org/10.1016/j.jgg.2024.10.013
韩国国度癌症中心Jaegal Shim团队发表估量论文，揭示TMEM39A与TMEM131在瑰丽隐杆线虫角质层变成经过中的伏击作用，通过调控大COPII囊泡的变成参与细胞外基质卵白的分泌，为东谈主类TMEM39关连疾病的致病机制估量提供新观念。
Integrated analysis and systematic characterization of the regulatory network for human germline development
Yashi Gu, Jiayao Chen, Ziqi Wang, Qizhe Shao, Zhekai Li, Yaxuan Ye, Xia Xiao, Yitian Xiao, Wenyang Liu, Sisi Xie, Lingling Tong, Jin Jiang, Xiaoying Xiao, Ya Yu, Min Jin, Yanxing Wei, Robert S. Young, Lei Hou, Di Chen
https://doi.org/10.1016/j.jgg.2024.11.005
浙江大学陈迪估量员团队发表估量论文，构建了一个全面的东谈主类原始生殖细胞数据库hPGCdb，ag百家乐两个平台对打可以吗包含RNA-seq、ATAC-seq、ChIP-seq、scRNA-seq等多组学高通量数据，基于体内与体外不同发育阶段的数据整合性分析，揭示了调控PGC发育的要津转录因子和调控麇集，并进行灵验性考据，为认识东谈主类生殖系关连疾病靶点提供新念念路。
Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish
Xiaojuan Guo, Liping Yang, Yujie Wang, Mengna Yuan, Wenqing Zhang, Xinyu He, Qiang Wang
https://doi.org/10.1016/j.jgg.2024.11.006
华南理工大学医学院王强教练团队发表估量论文，揭示了Wnt2bb信号在咽部软骨发育经过中的伏击作用，咽区外胚层开端的Wnt2bb信号通过经典Wnt/β-catenin通路激活Yap抒发，促进咽部软骨前体细胞增殖和软骨细胞熟谙。
Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM
Chongge Pan, Yali Hou, Yanting Hou, Ruizhen Wang, Meiyu Qian, Xue Bai, Maodi Liang, Jingzhou Wang, Jie Liu, Qianqian Wei, Ziyan Pan, Ting Wang, Chenyu Hu, Kun Xiang, Chun Yang, Cuizhe Wang, Hua Chen, Jun Zhang
https://doi.org/10.1016/j.jgg.2024.11.011
石河子大学新疆场所与民族高发病汲引部重心践诺室张君教练团队发表估量论文，揭示了脂肪组织源性的miR-548ab促进痴肥和T2DM的分子机制，为包含T2DM在内的临床常见葡萄糖代谢繁芜性疾病的认真和诊疗提供灵验靶标。
Resource
Genomic insights into demographic history, structural variation landscape, and complex traits from 514 Hu sheep genomes
Kaiyu Chen, Yuelang Zhang, Yizhe Pan, Xin Xiang, Chen Peng, Jiayi He, Guiqing Huang, Zhengguang Wang, Pengju Zhao
https://doi.org/10.1016/j.jgg.2024.11.015
浙江大学动物科学学院王争脸/赵鹏举团队发表估量论文，认识了湖羊品种的选拔信号和种群历史，并马虎了湖羊结构变异的特征过火与多种复杂性状的关联，为保种和育种责任提供了参考。
PAMPHLET: PAM Prediction HomoLogous-Enhancement Toolkit for precise PAM prediction in CRISPR-Cas systems
Chen Qi, Xuechun Shen, Baitao Li, Chuan Liu, Lei Huang, Hongxia Lan, Donglong Chen, Yuan Jiang, Dan Wang
https://doi.org/10.1016/j.jgg.2024.10.014
北京师范大学-香港浸会大学蚁合海外学院王丹助理教练团队发表估量论文，建造CRISPR-Cas系统PAM序列预测新器用PAMPHLET (https://github.com/GolshkovQ/PAMPHLET)，该器用通过同源增强才智来推广绝交子数据集，克服了现存器用处置有限绝交子序列数目时的局限性，从而权贵提升PAM预测准确性，减少假阳性效用。
Research Communications
Improved chromosome-level donkey (Equus asinus) genome provides insights into genome and chromosome evolution
Ge Yang, Mian Gong, Qi-Meng Yang, Yi-Dan Li, Jafari Halima, Chu-Zhao Lei, Yu Jiang, Rui-Hua Dang
https://doi.org/10.1016/j.jgg.2024.11.002
西北农林科技大学动物基因组与基因功能团队党瑞华/姜雨团队发表估量论文ag百家乐真的假的，应用三代测序时候(PacBio HiFi)、Hi-C测序拼装取得高质地染色体水平的家驴基因组，并磋议了驴的基因组和染色体演化，为异日驴功能基因组学和马属动物演化估量提供了伏击参考基因组资源。