All Papers
1. MicroRNAs unveiled: Nobel recognition of a revolutionary gene regulation mechanism
通信作家：申恩志
The 2024 Nobel Prize in Physiology or Medicine honored Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNAs (miRNAs), small non-coding RNA molecules that regulate gene expression by binding to target mRNAs. Initially identified in Caenorhabditis elegans, miRNAs were later found to be conserved across species and play crucial roles in development, immune response, and disease. miRNAs are transcribed as pri-miRNAs, processed into pre-miRNAs by Drosha/DGCR8, and matured by Dicer in the cytoplasm. They regulate gene expression post-transcriptionally through seed sequences, influencing processes like cell differentiation, apoptosis, and metabolism. Dysregulated miRNAs are implicated in cancers, cardiovascular diseases, neurological disorders, and metabolic conditions, making them promising therapeutic targets and diagnostic biomarkers. Beyond miRNAs, the Nobel recognition has spurred interest in other small RNAs, such as piRNAs and siRNAs, which also contribute to gene regulation and genome integrity. Future research will continue to explore the diverse roles of small RNAs and their potential applications in medicine and agriculture.
援用：
Xue J, Zhang G, Shen E. MicroRNAs unveiled: Nobel recognition of a revolutionary gene regulation mechanism.hLife2024; 3: 1–4.
2. Altitude adaptation: The unseen work of gut microbiota
hLife | 高原稳当新视角：肠说念菌群的作用及后劲
通信作家：毕玉晶，杨瑞馥
本文系统综述了肠说念菌群与高原稳当标的的相关推崇，以期为改善高原反馈提供表面相沿。
援用：
Guo J, Zhao R, Li K, et al. Altitude adaptation: The unseen work of gut microbiota.hLife2024; 3: 5–20.
3. Induction of translation-suppressive G3BP1+stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA
通信作家：Vladimir Majerciak
Transfected plasmid DNA induces stress granule (SG) formation.
Transfected plasmid DNA induces cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) condensates (cGC) and interferon responses.
Transfected plasmid DNA induced SG and cGC are mutually exclusive.
Inhibition of SG promotes transgene expression.
援用：
Majerciak V, Zheng ZM. Induction of translation-suppressive G3BP1+ stress granules and interferon-signaling cGAS condensates by transfected plasmid DNA.hLife2024; 3: 21–37.
4.DrosophilaCul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense
hLife | Cul3/Diap2/Dredd免疫驻防退换轴：为相关疾病调理提供新念念路
通信作家：蔡阐述，计山明
本相关深刻计划了Cullin眷属卵白Cul3在果蝇抗菌免疫驻防中的功能及分子机制。鉴于Cullin眷属卵白和先天免疫信号通路在果蝇和哺乳动物中的高保守性，此项相关将对临床上相关疾病的调理提供新念念路。
援用：
Kong F, Wang Z, Zhang C, et al.DrosophilaCul3 contributes to Diap2-mediated innate immune signaling for antimicrobial defense.hLife2024; 3: 38–51.
5. Diversity of reverse-transcriptase-containing viruses through global metagenomics
hLife | 病毒逆转录酶：从进化到功能的深度解析
通信作家：梁彦韬，ag百家乐下载Andrew McMinn，汪岷
该相关对病毒逆转录酶的系统挖掘和全面分析揭示了它们在进化和功能方面的各样性，有助于激动发展新式遗传器具和药物靶点。该相关加深了咱们对环境中病毒-微生物相互作用的贯通，以及病毒对东说念主类肠说念微生物群落稳态的孝顺。
援用：
Zheng Kag百家乐接口多少钱, Liang Y, Zhang Y, et al. Diversity of reverse-transcriptase-containing viruses through global metagenomics.hLife2024; 3: 52–56.